The Human Protein Atlas and HAI antibody catalogue

11 Jun 2008

Wednesday 11 June 2008

Time: 4.00 to 5.00 pm

Bio21 Institute Auditorium, 30 Flemington Rd, Parkville

Fredrik Ponten and Caroline Kampf of HUPO (Human Proteomics) human antibody initiative will be presenting at the Bio21 Institute. 

About: The completion of the human genome sequence has opened up a possibility for global expression profiling of human tissues and cells, allowing for comparative studies between normal and disease tissues. A multi-disciplinary program has created  a "Human Proteome Resource" by systematic exploration of the human proteome using antibody-based tissue proteomics, combining high-throughput generation of mono-specific antibodies (affinity-purified) with protein profiling in human tissues and cells using tissue microarrays. Recombinant protein fragments selected from unique regions called Protein Epitope Signatures Tags (PrESTs) were used as immunogens to generate antibodies. Analysis of protein expression patterns was performed on tissue and cell microarrays containing >700 spots of normal and cancer tissues as well as in vitro cultured cells.  Read more.