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The Dhillon lab focuses on understanding how deregulated signal transduction events contribute to the initiation and progression of cancers. Their work centres on signalling in the ERK pathway, which regulates critical processes involved in the growth and spread of cancers, including cell division, growth, survival, differentiation, migration and invasion. The groups research focuses on two major topics: (i) the Raf protein kinases, which regulate activation of the ERK pathway, and (ii) the Activator Protein-1 (AP-1) transcription factor complex, a major downstream target of the pathway.
Current projects include studying how AP-1 complexes regulate tumour cell invasion, and examining the role of Raf protein isoforms in regulating the tumour growth.
Techniques: RNA interference-based approaches to silence gene expression (e.g. siRNA, shRNA); cell-based assays of growth, proliferation, apoptosis, transformation and invasion; protein expression and purification; subcellular fractionation; protein kinase assays; fluorescence-based imaging; transcription factor activity assays, proteomic techniques; general molecular biology and cell biological techniques.
Amardeep Dhillon Bio
Dr Dhillon obtained his PhD from the University of Western Australia in 1998, and subsequently moved to the Beatson Institute for Cancer Research in Scotland for his postdoctoral studies. In 1994, he was promoted to the post of senior research scientist in the Cell signalling and Proteomics laboratory at the Beatson Institute. He returned to Australia in November 2007 to take up the Biochemistry Fund Fellowship at the University of Melbourne/Bio21 Institute. Since returning, he has established a research laboratory that is studying how deregulated signal transduction and transcriptional events contribute to the pathogenesis of cancers.
Dhillon Research Group
Research Staff
Postgraduate Students
- Omer Gilan
- Jeannine Diesch
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