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The Hutton group's research focus is in the areas of amino acid, peptide and protein chemistry.
Our research areas range from the development of new synthetic methods for the preparation of amino acids, through the total synthesis of complex cyclic peptides with potent biological activities, to the structure-based design of enzyme inhibitors and determination of enzymatic reaction mechanisms and stereochemistry.
Specific interests:
1. Cross-linked amino acids in peptides and proteins focusing on the role of dityrosine cross-linked Aβ peptide dimers in Alzheimer's disease, synthesis of biologically active cyclic peptide natural products, new methods for the stereocontrolled synthesis of amino acids.
2. Inhibitors of enzymes in the lysine biosynthetic pathway focusing on design and synthesis of inhibitors of enzymes of the lysine biosynthetic pathway as potential new antibacterial agents.
Techniques and specialities in the lab include: synthetic organic chemistry, asymmetric synthesis, peptide synthesis (solution and solid-phase).
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Craig Hutton Bio
Craig Hutton obtained his undergraduate and PhD degrees from the University of Adelaide before completing postdoctoral studies at the University of California, Berkeley and The University of Melbourne (Australian Postdoctoral Research Fellow). He was then appointed to the School of Chemistry at The University of Sydney, before returning to The University of Melbourne in 2003. His research interests include the stereocontrolled synthesis of unusual amino acids and biologically active cyclic peptides, and the design and synthesis of inhibitors of enzymes in the lysine biosynthetic pathway.
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Hutton Research Group
Postgraduate Students
- Nathan Fifer
- Barbara Wong (Li)
- Voula Mitsakos
- Quentin Churches
- Woan Mei Kok
- Shan Sun
- Lilian Hor
Honours Students
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